Take Quiz: Pharmacology quiz 8

Question 1

What is the primary role of P-glycoprotein in pharmacology?*

A. Binds to receptors to induce pharmacological effects

B. Enhances drug absorption in the gastrointestinal tract

C. Catalyzes the breakdown of drugs in the liver

D. Pumps drugs out of cells, reducing drug accumulation

Question 2

What is the primary role of P-glycoprotein in pharmacology?*

A. Binds to receptors to induce pharmacological effects

B. Enhances drug absorption in the gastrointestinal tract

C. Catalyzes the breakdown of drugs in the liver

D. Pumps drugs out of cells, reducing drug accumulation

Question 3

An agonist is a substance that:*

A. Blocks the action of a receptor

B. Competes with another drug at the receptor

C. Activates a receptor to produce a biological response

D. Reduces the potency of other drugs

Question 4

Which factor does not directly influence drug-receptor binding?*

A. Receptor density

B. Affinity of the drug for the receptor

C. Drug metabolism rate

D. Concentration of the drug

Question 5

Which phase of clinical trials focuses on safety in healthy volunteers?*

A. Phase IV

B. Phase III

C. Phase II

D. Phase I

Question 6

Which term best describes the amount of drug required to produce a therapeutic effect?*

A. Affinity

B. Selectivity

C. Efficacy

D. Potency

Question 7

What is the term for the dose of a drug that produces a response in 50% of the population?*

A. IC50

B. ED50

C. TD50

D. LD50

Question 8

Which of the following describes zero-order kinetics?*

A. A constant percentage of the drug is eliminated per unit time

B. Drug elimination is independent of concentration

C. A constant amount of drug is eliminated per unit time

Question 9

What term describes the decrease in response to a drug over repeated use?*

A. First-pass effect

B. Synergism

C. Tachyphylaxis

D. Potentiation

Question 10

Which type of receptor requires the longest time to elicit a cellular response?*

A. Nuclear receptors

B. G-protein coupled receptors

C. Tyrosine kinase receptors

D. Ion channel receptors

Question 11

A drug with a high first-pass effect will:*

A. Have reduced bioavailability

B. Have a long half-life

C. Exhibit rapid systemic absorption

D. Be excreted primarily in the kidneys