Question 1

A drug with a high therapeutic index is considered:*

A. Safer

B. More potent

C. Equally effective as a drug with a low therapeutic index

D. More dangerous

Question 2

An antagonist is a drug that:*

A. Binds to a receptor without affecting its activity

B. Competes with an agonist and blocks receptor activity

C. Enhances the action of an agonist

D. Activates a receptor to produce a biological response

Question 3

Which type of receptor interaction involves the drug binding but not activating the receptor?*

A. Partial agonist

B. Inverse agonist

C. Antagonist

D. Full agonist

Question 4

What is pharmacodynamics?*

A. The study of drug absorption, distribution, metabolism, and excretion

B. The study of drug toxicity and adverse effects

C. The study of the mechanisms of drug action and the relationship between drug concentration and effect

D. The study of the origin and chemical structure of drugs

Question 5

What does a steep dose-response curve indicate?*

A. High drug potency

B. Small changes in dose cause large changes in effect

C. Reduced drug efficacy

D. Wide therapeutic index

Question 6

Which of the following processes is primarily responsible for drug absorption?*

A. Diffusion

B. Distribution

C. Excretion

D. Metabolism

Question 7

In the context of signal transduction, second messengers such as cAMP are involved in:*

A. Increasing drug metabolism

B. Mediating the intracellular effects of receptor activation

C. Inhibiting agonist binding

D. Directly activating receptors

Question 8

The phenomenon in which the response to a drug decreases with continuous use is called:*

A. Sensitization

B. Dependence

C. Tolerance

D. Synergism

Question 9

Which of the following best describes a drug’s efficacy?*

A. The ability of a drug to bind to a receptor

B. The time it takes for a drug to achieve its peak effect

C. The maximum effect a drug can produce, regardless of dose

D. The dose required to produce 50% of the drug’s maximal effect

Question 10

The area under the plasma concentration-time curve (AUC) is used to determine:*

A. Drug distribution

B. Drug half-life

C. Bioavailability

D. Drug clearance

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